HnRNP M expression rescues neurodegeneration in neuronal intranuclear inclusion disease mouse model by restoring dysregulated RNA splicing and transcription

Abstract Background Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease caused by the expanded GGC repeats in the NOTCH2NLC gene, yet its underlying pathogenic mechanisms remains to be fully elucidated. Previous study suggests that hnRNP M, an RNA-binding protein sequestere...

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Autors principals:	Yongcheng Pan, Yangping Li, Ying Jiang, Xinhui Wang, Juan Wan, Qiying Sun, Yun Tian, Lu Shen, Hong Jiang, Beisha Tang, Bing Yao, Qiong Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Cell & Bioscience
Matèries:	NIID Neurodegeneration HnRNP M RNA transcription RNA splicing
Accés en línia:	https://doi.org/10.1186/s13578-025-01477-9
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