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HnRNP M expression rescues neurodegeneration in neuronal intranuclear inclusion disease mouse model by restoring dysregulated RNA splicing and transcription

Abstract Background Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease caused by the expanded GGC repeats in the NOTCH2NLC gene, yet its underlying pathogenic mechanisms remains to be fully elucidated. Previous study suggests that hnRNP M, an RNA-binding protein sequestere...

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Principais autores: Yongcheng Pan, Yangping Li, Ying Jiang, Xinhui Wang, Juan Wan, Qiying Sun, Yun Tian, Lu Shen, Hong Jiang, Beisha Tang, Bing Yao, Qiong Liu
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-10-01
Series:Cell & Bioscience
Assuntos:
NIID
Neurodegeneration
HnRNP M
RNA transcription
RNA splicing
Acceso en liña:https://doi.org/10.1186/s13578-025-01477-9
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