क्यूआर कोड

Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL

Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by NOTCH3 mutation. The condition leads to recurrent ischemic strokes, vascular dementia, early-onset and high disability, and its preval...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Lijun Long, Danni Wu, Xiaoyan Xiong, Huihui Xiong, Xuecheng Qiu, Suning Ping
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BMC 2025-12-01
श्रृंखला:Cell Communication and Signaling
विषय:
CADASIL
SUMOylation
Vascular smooth muscle cell
NOTCH3 cleavage
ऑनलाइन पहुंच:https://doi.org/10.1186/s12964-025-02556-7
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