Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling

Summary: Designing new functional motifs with unique properties is an important objective in the realm of synthetic biology. We uncover emergent properties of positive feedback loops (PFLs) under dual input signaling using pseudo potential energy-based high-throughput bifurcation analysis. We show t...

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Detalhes bibliográficos

Principais autores:	Soutrick Das, Debashis Barik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-04-01
coleção:	iScience
Assuntos:	Mathematical biosciences Systems biology Data processing in systems biology Synthetic biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S258900422300456X
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