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Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling

Summary: Designing new functional motifs with unique properties is an important objective in the realm of synthetic biology. We uncover emergent properties of positive feedback loops (PFLs) under dual input signaling using pseudo potential energy-based high-throughput bifurcation analysis. We show t...

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Autori principali: Soutrick Das, Debashis Barik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-04-01
Serie:iScience
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Accesso online:http://www.sciencedirect.com/science/article/pii/S258900422300456X
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