Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles

Summary: Immunodeficiencies are typically caused by loss-of-function mutations in lymphocyte-specific genes. Occasionally, mutations in ubiquitous general-purpose factors, including those affecting essential components of the DNA polymerase epsilon (POLE) holoenzyme, have cell-type-specific conseque...

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Hlavní autoři:	Iliana Siamishi, Norimasa Iwanami, Thomas Clapes, Eirini Trompouki, Connor P. O’Meara, Thomas Boehm
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2020-06-01
Edice:	Cell Reports
Témata:	DNA polymerase epsilon T cell B cell lymphopoiesis non-replicative function
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124720307361
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