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Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles

Summary: Immunodeficiencies are typically caused by loss-of-function mutations in lymphocyte-specific genes. Occasionally, mutations in ubiquitous general-purpose factors, including those affecting essential components of the DNA polymerase epsilon (POLE) holoenzyme, have cell-type-specific conseque...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Iliana Siamishi, Norimasa Iwanami, Thomas Clapes, Eirini Trompouki, Connor P. O’Meara, Thomas Boehm
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020-06-01
Schriftenreihe:Cell Reports
Schlagworte:
DNA polymerase epsilon
T cell
B cell
lymphopoiesis
non-replicative function
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124720307361
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