Integrated bulk and single-cell transcriptomic analyses identify transcriptome-defined groups and EGFR-associated microenvironmental programs in glioma

Abstract Background Glioma exhibits significant molecular heterogeneity, necessitating improved understanding of molecular subtypes for personalized treatment strategies. Methods This study integrated bulk RNA sequencing (GSE35169) to derive transcriptome-defined groups and single-cell RNA sequencin...

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Principais autores:	Yuanhan Wang, Long Li, Xing Hu, Longhu Han, Yihan Zhang, Zhisen Zhou, Wei Liu, Song Yang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer 2026-05-01
Series:	Discover Oncology
Assuntos:	Glioma Molecular subtypes Single-cell RNA sequencing EGFR Tumor microenvironment
Acceso en liña:	https://doi.org/10.1007/s12672-026-05138-2
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