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Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis

Abstract Objective We aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in osteosarcoma patients by evaluating the effect of gene polymorphism on adverse reactions of HD-MTX usage. Methods Several databases were combed for res...

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Autores principales: Ben Liu, Gang Liu, Binbin Liu, Yao Guo, Ningning Peng, Tiejun Li
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2024-01-01
Colección:World Journal of Surgical Oncology
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Acceso en línea:https://doi.org/10.1186/s12957-023-03287-0
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