Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis

Abstract Objective We aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in osteosarcoma patients by evaluating the effect of gene polymorphism on adverse reactions of HD-MTX usage. Methods Several databases were combed for res...

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Detalhes bibliográficos

Principais autores:	Ben Liu, Gang Liu, Binbin Liu, Yao Guo, Ningning Peng, Tiejun Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-01-01
Colecção:	World Journal of Surgical Oncology
Assuntos:	High-dose Methotrexate Adverse Reactions Osteosarcoma Gene Polymorphism Meta-analysis
Acesso em linha:	https://doi.org/10.1186/s12957-023-03287-0
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