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CRISPR library screening to develop HEK293-derived cell lines with improved lentiviral vector titers

Lentiviral (LV) vectors have emerged as powerful tools for treating genetic and acquired human diseases. As clinical studies and commercial demands have progressed, there has been a growing need for large amounts of purified LV vectors. To help meet this demand, we developed CRISPR library screening...

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Principais autores: Brian J. Iaffaldano, Michael P. Marino, Jakob Reiser
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-07-01
coleção:Frontiers in Genome Editing
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgeed.2023.1218328/full
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