A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor

Abstract The P2X7 receptor is an ATP-gated ion channel that activates inflammatory pathways involved in diseases such as cancer, atherosclerosis, and neurodegeneration. However, despite the potential benefits of blocking overactive signaling, no P2X7 receptor antagonists have been approved for clini...

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Bibliografiske detaljer

Principais autores:	Adam C. Oken, Andreea L. Turcu, Eva Tzortzini, Kyriakos Georgiou, Jessica Nagel, Franka G. Westermann, Marta Barniol-Xicota, Jonas Seidler, Ga-Ram Kim, So-Deok Lee, Annette Nicke, Yong-Chul Kim, Christa E. Müller, Antonios Kolocouris, Santiago Vázquez, Steven E. Mansoor
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-09-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-62643-8
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