A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor

Abstract The P2X7 receptor is an ATP-gated ion channel that activates inflammatory pathways involved in diseases such as cancer, atherosclerosis, and neurodegeneration. However, despite the potential benefits of blocking overactive signaling, no P2X7 receptor antagonists have been approved for clini...

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Detalhes bibliográficos

Principais autores:	Adam C. Oken, Andreea L. Turcu, Eva Tzortzini, Kyriakos Georgiou, Jessica Nagel, Franka G. Westermann, Marta Barniol-Xicota, Jonas Seidler, Ga-Ram Kim, So-Deok Lee, Annette Nicke, Yong-Chul Kim, Christa E. Müller, Antonios Kolocouris, Santiago Vázquez, Steven E. Mansoor
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-09-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-62643-8
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