Studying Spatial Protein Quality Control, Proteopathies, and Aging Using Different Model Misfolding Proteins in S. cerevisiae

Protein quality control (PQC) is critical to maintain a functioning proteome. Misfolded or toxic proteins are either refolded or degraded by a system of temporal quality control and can also be sequestered into aggregates or inclusions by a system of spatial quality control. Breakdown of this concer...

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Hauptverfasser:	Kara L. Schneider, Thomas Nyström, Per O. Widlund
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2018-07-01
Schriftenreihe:	Frontiers in Molecular Neuroscience
Schlagworte:	protein quality control spatial protein quality control protein misfolding misfolding model inclusions aging
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00249/full
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