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Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

Abstract Background Investigation of basic chronic inflammatory mechanisms and development of new therapeutics targeting the respiratory tract requires appropriate testing systems, including those to monitor long- persistence. Human precision-cut lung slices (PCLS) have been demonstrated to mimic th...

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Principais autores: Vanessa Neuhaus, Dirk Schaudien, Tatiana Golovina, Ulla-Angela Temann, Carolann Thompson, Torsten Lippmann, Claus Bersch, Olaf Pfennig, Danny Jonigk, Peter Braubach, Hans-Gerd Fieguth, Gregor Warnecke, Vidadi Yusibov, Katherina Sewald, Armin Braun
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2017-05-01
Series:Journal of Occupational Medicine and Toxicology
Assuntos:
Precision-cut lung slices
PCLS
Long-term cultivation
Bronchoconstriction
Human
Cytokines
Acceso en liña:http://link.springer.com/article/10.1186/s12995-017-0158-5
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