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Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations

Abstract The performance of CRISPR‐mediated genome editing near inverted repeats (IRs) potentially results in chromosomal translocations and other catastrophic rearrangements. However, the extent of this risk may be significantly underestimated because current reporter systems focus solely on site‐s...

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Principais autores: Zhiyang Hou, Qiyi Yi, Mengying Wu, Lijun Wu, Fanghua Li, Ting Wang, Po Bian
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-06-01
coleção:Advanced Science
Assuntos:
alternative end‐joining
chromosomal rearrangement
CRISPR‐mediated genome editing
DNA single‐strand annealing
nontargeted translocation
Acesso em linha:https://doi.org/10.1002/advs.202414415
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