Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations

Abstract The performance of CRISPR‐mediated genome editing near inverted repeats (IRs) potentially results in chromosomal translocations and other catastrophic rearrangements. However, the extent of this risk may be significantly underestimated because current reporter systems focus solely on site‐s...

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Autors principals:	Zhiyang Hou, Qiyi Yi, Mengying Wu, Lijun Wu, Fanghua Li, Ting Wang, Po Bian
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-06-01
Col·lecció:	Advanced Science
Matèries:	alternative end‐joining chromosomal rearrangement CRISPR‐mediated genome editing DNA single‐strand annealing nontargeted translocation
Accés en línia:	https://doi.org/10.1002/advs.202414415
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