Epitope-specific mechanisms of IGF1R inhibition by ganitumab.

BACKGROUND: Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future human therapeutics depends on understanding the specific mechanisms by which these antibodies target IGF1R signaling. METHODOLOGY/P...

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Principais autores:	Frank J Calzone, Elaina Cajulis, Young-Ah Chung, Mei-Mei Tsai, Petia Mitchell, John Lu, Ching Chen, Jilin Sun, Robert Radinsky, Richard Kendall, Pedro J Beltran
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2013-01-01
叢編:	PLoS ONE
在線閱讀:	http://europepmc.org/articles/PMC3562316?pdf=render
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