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Increasing in vivo drug exposure levels of compound WX-081 (sudapyridine) when used in combination with clofazimine or clarithromycin

ABSTRACT To examine the in vivo distribution of WX-081 alone or in combination with clarithromycin (Clr) or clofazimine (CFZ) in rats infected with Mycobacterium abscessus and evaluate the effects of the interactions of WX-081 with Clr and CFZ on its tissue distribution, the concentrations of WX-081...

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Main Authors: Xueyu Wang, Shan Gao, Xia Yu, Yongguo Li, Lei Li, Naihui Chu, Hairong Huang, Wenjuan Nie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2026-04-01
Series:Microbiology Spectrum
Subjects:
WX-081
clarithromycin
clofazimine
drug distribution
Mycobacterium abscessus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01555-25
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