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Genome-Wide Analysis of Serial Passage of the Infectious Bronchitis Virus Reveals Evolutionary Dynamics Underlying Attenuation and Immunogenicity

<b>Background/Objectives</b>: Serial passage in embryonated eggs is widely used to attenuate the infectious bronchitis virus (IBV) for vaccine production; however, the evolutionary processes underlying attenuation and immunogenicity remain incompletely understood. Here, we analyzed genome-wide viral...

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Hlavní autoři: Joaquín Williman, Gonzalo Tomas, Ariel Vagnozzi, Claudia Techera, Sebastián Brambillasca, Ruben Pérez, Ana Marandino
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2026-05-01
Edice:Vaccines
Témata:
IBV
serial passage
attenuation
Spike protein
viral evolution
quasispecies
On-line přístup:https://www.mdpi.com/2076-393X/14/6/467
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