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Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study

Abstract Objective The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the innate immune system which is an important contributor to pathology in...

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Principais autores: Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-12-01
Serier:Arthritis Research & Therapy
Fag:
Systemic sclerosis
Pulmonary fibrosis
CAR-T cell therapy
NK cells
NKG2A
Fcγ receptor
Online adgang:https://doi.org/10.1186/s13075-024-03451-1
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