Nucleotide excision repair and poly(ADP-ribose) polymerase 1 cooperate in HBV cccDNA synthesis: A potential viral therapeutic target

Background & Aims: Blocking the synthesis of HBV covalently closed circular (ccc)DNA is crucial for achieving a viral cure. Previous work showed that inhibiting nucleotide excision repair (NER) reduced cccDNA levels in HBV-producing liver cells. Here, we aimed to clarify the role of NER endonucl...

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Main Authors:	Hsu-Chin Hung, Hung-Wen Tsai, Yung-Tsung Li, Wen-Chun Liu, Kuang-Hsiung Cheng, Chia-Jui Yen, Yun-Ping Lee, Yuan-Hsin Fang, Cheng-Hsiang Chuang, Hui-Lin Wu, Ting-Tsung Chang, Wenya Huang
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-06-01
Series:	JHEP Reports
Subjects:	HBV cccDNA Nucleotide excision repair PARP1 Olaparib
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589555926000777
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