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Replication-driven HBV cccDNA loss in chimeric mice with humanized livers

ABSTRACT Hepatitis B virus (HBV) infection depends on the establishment of covalently closed circular DNA (cccDNA) and can be either transient or persistent. Persistent infection requires a noncytopathic viral phenotype, primarily achieved by limiting replication in infected cells. This study aimed...

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Hlavní autoři: Bai-Hua Zhang, Yuanping Zhou, Stephen Horrigan, Fabien Zoulim, Jianming Hu, Yong-Yuan Zhang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2025-11-01
Edice:Journal of Virology
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On-line přístup:https://journals.asm.org/doi/10.1128/jvi.01295-25
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