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LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by rapid progression. The mechanisms that lead to a shift from initial therapeutic sensitivity to ultimate therapeutic resistance are poorly understood. Although the SCLC genomic landscape led to the discovery of promi...

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Principais autores: Takanobu Jotatsu, Shigehiro Yagishita, Ken Tajima, Fumiyuki Takahashi, Kaoru Mogushi, Moulid Hidayat, Aditya Wirawan, Ryo Ko, Ryota Kanemaru, Naoko Shimada, Keiko Mitani, Tsuyoshi Saito, Kazuya Takamochi, Kenji Suzuki, Shinji Kohsaka, Shinya Kojima, Hiroshi Mukae, Kazuhiro Yatera, Kazuhisa Takahashi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-03-01
coleção:Biochemistry and Biophysics Reports
Assuntos:
LSD1
LSD1+8a
KDM
SCLC
Neuroendocrine marker
Resistance to chemotherapy
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405580816303235
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