Deletion of histone demethylase Lsd1 (Kdm1a) during retinal development leads to defects in retinal function and structure

PurposeThe purpose of this study was to investigate the role of Lysine specific demethylase 1 (Lsd1) in murine retinal development. LSD1 is a histone demethylase that can demethylate mono- and di-methyl groups on H3K4 and H3K9. Using Chx10-Cre and Rho-iCre75 driver lines, we generated novel transgen...

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Autors principals:	Salma Ferdous, Debresha A. Shelton, Tatiana E. Getz, Micah A. Chrenek, Nancy L’Hernault, Jana T. Sellers, Vivian R. Summers, P. Michael Iuvone, Jeremy M. Boss, Jeffrey H. Boatright, John M. Nickerson
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-02-01
Col·lecció:	Frontiers in Cellular Neuroscience
Matèries:	retina Lsd1 Kdm1a neuroepigenetics retinal degeneration neurodegeneration
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1104592/full
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