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SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions

Summary: The rixosome and PRC1 silencing complexes are associated with deSUMOylating and deubiquitinating enzymes, SENP3 and USP7, respectively. How deSUMOylation and deubiquitylation contribute to rixosome- and Polycomb-mediated silencing is not fully understood. Here, we show that the enzymatic ac...

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Hauptverfasser: Haining Zhou, Wenzhi Feng, Juntao Yu, Tiasha A. Shafiq, Joao A. Paulo, Jiuchun Zhang, Zhenhua Luo, Steven P. Gygi, Danesh Moazed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2023-04-01
Schriftenreihe:Cell Reports
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Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124723003509
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