OVX033, a nucleocapsid-based vaccine candidate, provides broad-spectrum protection against SARS-CoV-2 variants in a hamster challenge model

Spike-based COVID-19 vaccines induce potent neutralizing antibodies but their efficacy against SARS-CoV-2 variants decreases. OVX033 is a recombinant protein composed of the full-length nucleocapsid (N) protein of SARS-CoV-2 genetically fused to oligoDOM®, a self-assembling domain which improves ant...

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Detalhes bibliográficos

Principais autores:	Charlotte Primard, Elodie Monchâtre-Leroy, Judith Del Campo, Séverine Valsesia, Elsa Nikly, Marion Chevandier, Franck Boué, Alexandre Servat, Marine Wasniewski, Evelyne Picard-Meyer, Thomas Courant, Nicolas Collin, Francisco J. Salguero, Alexandre Le Vert, Delphine Guyon-Gellin, Florence Nicolas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-06-01
Colecção:	Frontiers in Immunology
Assuntos:	recombinant nucleocapsid universal vaccine broad-spectrum protection cross-reactive immune responses lung histopathology lung viral load
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188605/full
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