DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes

BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.

Detalhes bibliográficos

Principais autores:	Emma A. Morrison, Julio C. Sanchez, Jehnna L. Ronan, Daniel P. Farrell, Katayoun Varzavand, Jenna K. Johnson, Brian X. Gu, Gerald R. Crabtree, Catherine A. Musselman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2017-07-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/ncomms16080
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