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Localization of the PelC and PelE effectors to the Legionella-containing vacuole through host-mediated prenylation and their role in intracellular proliferation

ABSTRACT Legionella pneumophila is an intracellular pathogen that replicates in macrophage and protozoan hosts within an endoplasmic reticulum (ER)-derived phagosome that evades the endosomal-lysosomal degradation pathway. The Dot/Icm Type IV Secretion System (T4SS) of L. pneumophila injects ~368 ef...

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Principais autores: Cheon Jee Shin, Christopher T. D. Price, Manal S. J. Da'as, Yousef Abu Kwaik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2026-04-01
coleção:Infection and Immunity
Assuntos:
prenylation
Prenylated Effectors of Legionella (Pel)
intracellular
trafficking
lysosomes
Acesso em linha:https://journals.asm.org/doi/10.1128/iai.00605-25
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