Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subarachnoid hemorrhage in rats

Abstract Background The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18. Fluoxetine has been shown to have the anti-inflammatory properties in many disease models. However, the effects and mech...

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Huvudupphov:	Jian-ru Li, Hang-zhe Xu, Sheng Nie, Yu-cong Peng, Lin-Feng Fan, Zhi-jiang Wang, Cheng Wu, Feng Yan, Jing-yin Chen, Chi Gu, Chun Wang, Jing-sen Chen, Lin Wang, Gao Chen
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2017-09-01
Serie:	Journal of Neuroinflammation
Ämnen:	Subarachnoid hemorrhage NLRP3 inflammasome Fluoxetine Inflammation Early brain injury Autophagy
Länkar:	http://link.springer.com/article/10.1186/s12974-017-0959-6
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