The intersection of homologous recombination (HR) and mismatch repair (MMR) pathways in DNA repair-defective tumors

Abstract Homologous recombination (HR) and mismatch repair (MMR) defects are driver mutational imprints and actionable biomarkers in DNA repair-defective tumors. Although usually thought as mutually exclusive pathways, recent preclinical and clinical research provide preliminary evidence of a functi...

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Autori principali:	Lorena Incorvaia, Tancredi Didier Bazan Russo, Valerio Gristina, Alessandro Perez, Chiara Brando, Clarissa Mujacic, Emilia Di Giovanni, Marco Bono, Silvia Contino, Carla Ferrante Bannera, Maria Concetta Vitale, Andrea Gottardo, Marta Peri, Antonio Galvano, Daniele Fanale, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-09-01
Serie:	npj Precision Oncology
Accesso online:	https://doi.org/10.1038/s41698-024-00672-0
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