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Mitochondrial DNA editing: Key to the treatment of neurodegenerative diseases

Neuronal death is associated with mitochondrial dysfunction caused by mutations in mitochondrial DNA. Mitochondrial DNA becomes damaged when processes such as replication, repair, and nucleotide synthesis are compromised. This extensive accumulation of damaged mitochondrial DNA subsequently disrupts...

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Principais autores: Ye Hong, Ying Song, Wenjun Wang, Jinghui Shi, Xi Chen
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2025-07-01
Serier:Genes and Diseases
Fag:
Base editor
CRISPR-Cas9
Mitochondrial DNA
mitoTALENs
mitoZFNs
Neurodegenerative diseases
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352304224002344
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