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Transcriptional dysregulation in a transgenic model of Parkinson disease

Alpha-synuclein has been implicated in Parkinson disease, yet the mechanism by which alpha-synuclein causes cell injury is not understood. Using a transgenic mouse model, we evaluated the effect of alpha-synuclein overexpression on gene expression in the substantia nigra. Nigral mRNA from wild type...

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Principais autores: Talene A. Yacoubian, Ippolita Cantuti-Castelvetri, Bérengère Bouzou, Georgios Asteris, Pamela J. McLean, Bradley T. Hyman, David G. Standaert
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2008-03-01
סדרה:Neurobiology of Disease
נושאים:
Parkinson disease
Alpha-synuclein
Microarray
Substantia nigra
Laser capture microdissection
Mouse
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S0969996107002616
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