De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system
Abstract Artificial assembly of small functional proteins provides effective strategies for development of compact RNA degradation systems, which overcome the challenges associated with delivery. Here, we excavate and evolve three small toxin endoribonucleases with simple RNA cleavage motifs (barnas...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2025-09-01
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| Colección: | Nature Communications |
| Acceso en línea: | https://doi.org/10.1038/s41467-025-63166-y |
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