ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

Abstract The transmembrane metalloprotease‐disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple‐negat...

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Autors principals:	Mathilde Romagnoli, Nora D Mineva, Michael Polmear, Catharina Conrad, Srimathi Srinivasan, Delphine Loussouarn, Sophie Barillé‐Nion, Irene Georgakoudi, Áine Dagg, Enda W McDermott, Michael J Duffy, Patricia M. McGowan, Uwe Schlomann, Maddy Parsons, Jörg W Bartsch, Gail E Sonenshein
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2013-12-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	ADAM8 cancer progression metastasis therapeutic target triple‐negative breast cancer
Accés en línia:	https://doi.org/10.1002/emmm.201303373
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