ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

Abstract The transmembrane metalloprotease‐disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple‐negat...

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Bibliografiska uppgifter

Huvudupphov:	Mathilde Romagnoli, Nora D Mineva, Michael Polmear, Catharina Conrad, Srimathi Srinivasan, Delphine Loussouarn, Sophie Barillé‐Nion, Irene Georgakoudi, Áine Dagg, Enda W McDermott, Michael J Duffy, Patricia M. McGowan, Uwe Schlomann, Maddy Parsons, Jörg W Bartsch, Gail E Sonenshein
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Springer Nature 2013-12-01
Serie:	EMBO Molecular Medicine
Ämnen:	ADAM8 cancer progression metastasis therapeutic target triple‐negative breast cancer
Länkar:	https://doi.org/10.1002/emmm.201303373
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