Clinical characteristics and genotype-phenotype correlation analysis of familial Alzheimer’s disease patients with pathogenic/likely pathogenic amyloid protein precursor mutations

Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with aging, environmental, and genetic factors. Amyloid protein precursor (APP) is a known pathogenic gene for familial Alzheimer’s disease (FAD), and now more than 70 APP mutations have been reported, but the genotype-ph...

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Principais autores:	Yingzi Liu, Xuewen Xiao, Hui Liu, Xinxin Liao, Yafang Zhou, Ling Weng, Lu Zhou, Xixi Liu, Xiang-yun Bi, Tianyan Xu, Yuan Zhu, Qijie Yang, Sizhe Zhang, Xiaoli Hao, Weiwei Zhang, Junling Wang, Bin Jiao, Lu Shen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Aging Neuroscience
Assuntos:	Alzheimer’s disease APP mutations clinical characteristics genotype-phenotypic non-dementia symptoms neurological symptoms
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.1013295/full
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