Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription

Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by 4R tau deposition in neurons as well as in astrocytes and oligodendrocytes. While astrocytic tau deposits are rarely observed in normal aging (so-called aging-related tau astrogliopathy, ARTAG) and Alzheime...

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Principais autores:	Rosemary J. Jackson, Alexandra Melloni, Dustin P. Fykstra, Alberto Serrano-Pozo, Leslie Shinobu, Bradley T. Hyman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2024-08-01
סדרה:	Acta Neuropathologica Communications
נושאים:	Progressive supranuclear palsy Astrocytes MAPT Tufted astrocytes Tau
גישה מקוונת:	https://doi.org/10.1186/s40478-024-01844-6
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