Key determinants of the dual clamp/activator function of Complexin

Complexin determines magnitude and kinetics of synchronized secretion, but the underlying molecular mechanisms remained unclear. Here, we show that the hydrophobic face of the amphipathic helix at the C-terminus of Complexin II (CpxII, amino acids 115–134) binds to fusion-promoting SNARE proteins, p...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Mazen Makke, Alejandro Pastor-Ruiz, Antonio Yarzagaray, Surya Gaya, Michelle Zimmer, Walentina Frisch, Dieter Bruns
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2024-11-01
Цуврал:	eLife
Нөхцлүүд:	exocytosis neurotransmitter release complexin
Онлайн хандалт:	https://elifesciences.org/articles/92438
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!