Graphasing: phasing diploid genome assembly graphs with single-cell strand sequencing

Abstract Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce de novo haplotype-resolved assemblies often require either difficult-to-acquire parental data or an intermediate haplotype-collapsed assembly. Here, we present Graphasing...

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主要な著者:	Mir Henglin, Maryam Ghareghani, William T. Harvey, David Porubsky, Sergey Koren, Evan E. Eichler, Peter Ebert, Tobias Marschall
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2024-10-01
シリーズ:	Genome Biology
主題:	De novo assembly Phasing Assembly graph Haplotype Strand-seq Hi-C
オンライン･アクセス:	https://doi.org/10.1186/s13059-024-03409-1
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