Graphasing: phasing diploid genome assembly graphs with single-cell strand sequencing

Abstract Haplotype information is crucial for biomedical and population genetics research. However, current strategies to produce de novo haplotype-resolved assemblies often require either difficult-to-acquire parental data or an intermediate haplotype-collapsed assembly. Here, we present Graphasing...

Полное описание

Библиографические подробности

Главные авторы:	Mir Henglin, Maryam Ghareghani, William T. Harvey, David Porubsky, Sergey Koren, Evan E. Eichler, Peter Ebert, Tobias Marschall
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-10-01
Серии:	Genome Biology
Предметы:	De novo assembly Phasing Assembly graph Haplotype Strand-seq Hi-C
Online-ссылка:	https://doi.org/10.1186/s13059-024-03409-1
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