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Overexpression of Mitochondrial Ferritin Enhances Blood–Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells

Blood–brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following cerebral ischemia reperfusion (I/R) injury can disru...

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Principais autores: Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-06-01
Serier:Antioxidants
Fag:
blood–brain barrier
ischemic stroke
mitochondrial ferritin
iron
endothelial cells
Online adgang:https://www.mdpi.com/2076-3921/11/7/1257
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