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Ultrasound-triggered microbubble delivery of voriconazole for enhanced reduction of Candida albicans biofilms in vitro

Aims: This study aimed to develop voriconazole-loaded microbubbles (MBs@VRC) combined with ultrasound-targeted microbubble destruction (UTMD) as a novel strategy to disrupt Candida albicans biofilms and enhance antifungal efficacy, addressing the critical challenge of biofilm-associated resistance i...

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Principais autores: Rui Liu, Liqin Yao, Qiangde Hu, Chen Zou, Boyong Xu, Li Cao, Wenbo Mu
Formato: Artigo
Idioma:Inglês
Publicado em: The British Editorial Society of Bone & Joint Surgery 2026-05-01
Colecção:Bone & Joint Research
Assuntos:
ultrasound-targeted microbubble destruction
voriconazole-loaded microbubbles
candida albicans
biofilms
titanium
staining
macrophages
periprosthetic joint infections (pjis)
scanning electron microscopy
microscopy
infections
adjunctive therapy
variance
Acesso em linha:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.155.BJR-2025-0459.R2
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