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Hexokinase 2 dimerization and interaction with voltage‐dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer

Abstract Gemcitabine (GEM) is the standard chemotherapy drug for pancreatic cancer. Because of widespread drug resistance, the effect is limited. Therefore, it is urgent to reveal the underlying mechanism. Glycolysis is the most remarkable character of tumor aberrant metabolism, which plays vital ro...

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Autori principali: Kun Fan, Zhiyao Fan, He Cheng, Qiuyi Huang, Chao Yang, Kaizhou Jin, Guopei Luo, Xianjun Yu, Chen Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2019-10-01
Serie:Cancer Medicine
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Accesso online:https://doi.org/10.1002/cam4.2463
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