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Small molecule inhibition of voltage dependent anion channel 1 reroutes mitochondrial metabolite flux

ABSTRACT: Voltage dependent anion channels (VDACs 1, 2 and 3) in the outer mitochondrial membrane control the flux of anions and oxidizable substrates that sustain mitochondrial metabolism. Nicotinamide adenine dinucleotide (NADH) closes VDAC by binding to a pocket, conserved in all isoforms, locate...

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Autori principali: Seyed Majed Modaresi, Leilei Zhang, Amir Ata Saei, Morris Degen, Mohammad Khavani, Hassan Gharibi, Ákos Végvári, Zhiwei Ye, Jie Zhang, Evgeny Pavlov, Elizabeth A. Jonas, Kenneth D. Tew, Sebastian Hiller, Danyelle M. Townsend, Eduardo N. Maldonado
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2026-07-01
Serie:Molecules and Cells
Soggetti:
Cancer metabolism
Glycolysis
Mitochondria
SC18
VDAC1
Accesso online:http://www.sciencedirect.com/science/article/pii/S1016847826000609
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