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Noncanonical DNA motifs as transactivation targets by wild type and mutant p53.

Sequence-specific binding by the human p53 master regulator is critical to its tumor suppressor activity in response to environmental stresses. p53 binds as a tetramer to two decameric half-sites separated by 0-13 nucleotides (nt), originally defined by the consensus RRRCWWGYYY (n = 0-13) RRRCWWGYYY...

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Principais autores: Jennifer J Jordan, Daniel Menendez, Alberto Inga, Maher Noureddine, Douglas A Bell, Michael A Resnick
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2008-06-01
סדרה:PLoS Genetics
גישה מקוונת:http://europepmc.org/articles/PMC2518093?pdf=render
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