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Prognostic and predictive impact of NOTCH1 mutations in patients with chronic lymphocytic leukemia: a tertiary single-center experience

NOTCH1 mutations (NOTCH1m) occur in 6%–12% of newly diagnosed chronic lymphocytic leukemia (CLL) patients, increasing to 15%–20% in relapsed cases. Despite their clinical relevance, the independent prognostic impact of NOTCH1m remains controversial, particularly in the era of targeted therapies, and...

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Kaydedildi:
Asıl Yazarlar: Mattia D’Antiga, Andrea Serafin, Francesco Angotzi, Alessandro Cellini, Arianna Bevilacqua, Giovanni Leone, Nicolò Danesin, Chiara Adele Cavarretta, Francesco Piazza, Erich Piovan, Laura Bonaldi, Livio Trentin, Andrea Visentin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2026-01-01
Seri Bilgileri:Frontiers in Oncology
Konular:
CLL
NOTCH1
overall survival
prognostic factors
target therapy
Online Erişim:https://www.frontiersin.org/articles/10.3389/fonc.2025.1726439/full
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