Prognostic and predictive impact of NOTCH1 mutations in patients with chronic lymphocytic leukemia: a tertiary single-center experience

NOTCH1 mutations (NOTCH1m) occur in 6%–12% of newly diagnosed chronic lymphocytic leukemia (CLL) patients, increasing to 15%–20% in relapsed cases. Despite their clinical relevance, the independent prognostic impact of NOTCH1m remains controversial, particularly in the era of targeted therapies, and...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Mattia D’Antiga, Andrea Serafin, Francesco Angotzi, Alessandro Cellini, Arianna Bevilacqua, Giovanni Leone, Nicolò Danesin, Chiara Adele Cavarretta, Francesco Piazza, Erich Piovan, Laura Bonaldi, Livio Trentin, Andrea Visentin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
coleção:	Frontiers in Oncology
Assuntos:	CLL NOTCH1 overall survival prognostic factors target therapy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1726439/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!