Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains

Abstract Background Large-scale genome-wide association studies have successfully identified many genetic variants significantly associated with Alzheimer’s disease (AD), such as rs429358, rs11038106, rs723804, rs13591776, and more. The next key step is to understand the function of these SNPs and t...

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Detalhes bibliográficos

Principais autores:	Pradeep Varathan, Priyanka Gorijala, Tanner Jacobson, Danai Chasioti, Kwangsik Nho, Shannon L. Risacher, Andrew J. Saykin, Jingwen Yan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-04-01
coleção:	BMC Medical Genomics
Assuntos:	GWAS Alzheimer’s Diseases eQTL HEIDI SMR
Acesso em linha:	https://doi.org/10.1186/s12920-022-01245-5
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