Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study

Abstract In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular hybridization theory, a novel series of isoindolin-1,3-dione-based acetohydrazides (compounds 8a–h) was designed, synthesized, and evaluated as possible acetylcholinesterase (AChE) and butyrylcholinesterase (BC...

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Hauptverfasser:	Ahmad Nazarian, Fahime Abedinifar, Haleh Hamedifar, Mohammad Hashem Hashempur, Mohammad Mahdavi, Nima Sepehri, Aida Iraji
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-04-01
Schriftenreihe:	BMC Chemistry
Schlagworte:	Acetylcholinesterase Butyrylcholinesterase Isoindolin-1,3-dione Molecular dynamics simulations
Online-Zugang:	https://doi.org/10.1186/s13065-024-01169-4
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